 |
Composition:
Terbinafine Hydrochloride - 250 mg tablets. |
| Mode of Action |
Terbinafine hydrochloride, a synthetic allylamine derivative, interferes with fungal ergosterol biosynthesis by inhibiting squalene epoxidase in the fungal cell membrane.
This leads to a deficiency of ergosterol and an intracellular accumulation of squalene, thus disrupting fungal membrane function and cell wall synthesis, and resulting in fungal cell death |
| Indication |
Tinea corporis, Tinea cruris,Tinea pedis, Tinea capitis
Toe nail & other types of Onychomycosis
|
| Dosage |
Children
No data are available in children under 2 years of age. Children weighing 20-40 kg: half tablet of Terbest 250 mg once a day.
Children weighing >40 kg: one tablet of Terbest 250 mg once a day. Adults
One tablet of Terbest once a day.
The duration of treatment varies according to the indication and the severity of the infection.
Skin Infections
Tinea pedis : 2 to 6 weeks.
Tinea corporis/cruris : 2 to 4 weeks
Tinea capitis : 4 weeks
Onychomycosis (Nail Infections)
Fingernail onychomycosis: 6 weeks
Toenail onychomycosis: 12 weeks |
| Side Effects |
COMMON
Gastrointestinal: Diarrhea (oral granules, 3% ; oral tablets, 5.6% )
Neurologic: Headache (oral granules, 7% ; oral tablet, 12.9% )
SERIOUS
Dermatologic: Cutaneous lupus erythematosus, Erythema multiforme, Stevens-Johnson syndrome, Toxic epidermal necrolysis
Hematologic: Agranulocytosis (rare ), Neutropenic disorder (Severe), Pancytopenia
Hepatic: Liver failure
Immunologic: Systemic lupus erythematosus
|
| Precautions |
Allergic conditions
Immune system problems
Kidney disease
Liver Disease
Lupus erythematosus
Limit alcoholic beverages
|
| Contraindications |
Hypersensitivity to Terbinafine Products |
| Pregnancy / lactation |
Use not recommended |
| Sales Pack |
Terbest : Pack of 7 tabs/box (1 x 7) |
